Antisense inhibition of ras p21 expression that is sensitive to a point mutation.

doi:10.1021/bi00098a001

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Article

Antisense inhibition of ras p21 expression that is sensitive to a point mutation.

Biochemistry - 27 Aug 1991

Chang E H, Miller P S, Cushman C, Devadas K, Pirollo K F, Ts'o P O, Yu Z P

Abstract excerpt

Many genetic disorders result from a single point mutation, and many tumor oncogenes have been found to be altered by a point mutation. The ability to inhibit selectively the expression of the mutated form of a protein without affecting its normal counterpart is central to many therapeutic strate...

Topics

Base Sequence
Carcinoma
Cell Line, Transformed
Gene Expression Regulation
Genes, ras
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Oligonucleotides, Antisense
Oncogene Protein p21(ras)
Organophosphorus Compounds

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