Article
p53 interference and growth inhibition in p53-mutant and overexpressing endometrial cancer cell lines.
Gynecologic oncology - 1 Jul 1997
Janicek M F, Angioli R, Unal A D, Sevin B U, Madrigal M, Estape R, Averette H E
Abstract excerpt
BACKGROUND: The presence of p53 mutations and associated mutant p53 overexpression has been demonstrated in many cancer systems. Whether the overexpression of mutant p53 represents cause or effect, and whether p53 mutation contributes actively to the malignant phenotype is a matter of controversy. We examined the growth effects of oligonucleotides designed to interfere with p53 expression and/or activity in...
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