Diminished activity of the first N-glycosylation enzyme, dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT), gives rise to mutant phenotypes in yeast.

doi:10.1016/0167-4838(94)00201-q

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Article

Diminished activity of the first N-glycosylation enzyme, dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT), gives rise to mutant phenotypes in yeast.

Biochimica et biophysica acta - 22 Feb 1995

Kukuruzinska M A, Lennon K

Abstract excerpt

The enzyme which initiates the dolichol pathway of protein N-glycosylation, dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT), is encoded by the ALG7 gene. Essential for viability, ALG7 has been evolutionarily conserved and shown to be involved in a variety of functions. ALG7 is an e...

Topics

Glycosylation
Mutation
Phenotype
Saccharomyces cerevisiae
Transferases (Other Substituted Phosphate Groups)

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