Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases.

Nucleic acids research - 11 Jan 1995

Seibel P, Trappe J, Villani G, Klopstock T, Papa S, Reichmann H

Abstract excerpt

Successes in classical gene therapies have been achieved by placing a corrected copy of a defective nuclear gene in cells. A similar gene replacement approach for a mutant mitochondrial genome is invariably linked to the use of a yet unavailable mitochondrial transfection vector. Here we show that DNA coupled covalently to a short mitochondrial leader peptide (chimera) can enter mitochondria via the protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Recombinant Fusion Proteins

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 7870573
DOI: 10.1093/nar/23.1.10
PMCID: PMC306624

Genes

OTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases.PMID 7870573Read ↗

Can Mitochondrial DNA be CRISPRized: Pro and Contra.Semantic proximity Read ↗

Recent Advances in Mitochondria-Targeted Gene Delivery.Semantic proximity Read ↗

Natural competence of mammalian mitochondria allows the molecular investigation of mitochondrial gene expressionSemantic proximity Read ↗

Rational Designs at the Forefront of Mitochondria-Targeted Gene Delivery: Recent Progress and Future Perspectives.Semantic proximity Read ↗

Progress and prospects: gene therapy for mitochondrial DNA disease.Semantic proximity Read ↗

Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.Semantic proximity Read ↗

Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells.Semantic proximity Read ↗

[MITO-Porter; a cutting-edge technology for mitochondrial gene therapy].Semantic proximity Read ↗

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?Semantic proximity Read ↗

In-vitro genetic modification of mitochondrial function.Semantic proximity Read ↗

Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment.Semantic proximity Read ↗

Gene therapy by mitochondrial transfer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.