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Article

1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain.

Journal of natural products - 27 Feb 2015

Sun Peng, Zhao Qunfei, Wu Zhuhua, Zhang Wen, Liu Wen

Abstract excerpt

Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed spectroscopic analysis. This is the first report of 1,19-seco-AVE analogues. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.

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Identifiers

PMID: 25611131
DOI: 10.1021/np500468f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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