Article
The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele.
FEBS letters - 13 Feb 1995
Yasuda T, Nadano D, Takeshita H, Tenjo E, Sawazaki K, Ootani M, Kishi K
Abstract excerpt
In addition to the three alleles commonly responsible for the protein polymorphism of human deoxyribonuclease I, a mutation encoded by a fourth allele, DNASE1*4, was detected by isoelectric focusing. All 8 exons covering the entire open reading frame of the human DNase I gene were amplified by th...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- Deoxyribonuclease I
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sequence Homology, Amino Acid