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Article

Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in systemic lupus erythematosus.

International journal of immunogenetics - 1 Feb 2010

AlFadhli Suad, AlTamimy Bader, Kharrat Najla, AlSaeid Khalid, Haider Mohamad Z, Rebai Ahmed

Abstract excerpt

Deoxyribonuclease I (DNASE1) may be responsible for the removal of DNA from nuclear antigens at sites of high cell turnover, thus preventing the onset of systemic lupus erythematosus (SLE). The purpose of this study was to screen DNASE1 gene for mutations that may have an effect on susceptibility to develop SLE. DNA was extracted from 76 Kuwaiti SLE patients and 92 race-matched controls. PCR-direct sequencing was...

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Source

Identifiers

PMID: 19863681
DOI: 10.1111/j.1744-313X.2009.00881.x

Genes

DNASE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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