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Article

T cell reconstitution by haploidentical BMT does not restore the diversification of the Ig heavy chain gene in patients with X-linked SCID.

Bone marrow transplantation - 1 Dec 1995

Minegishi Y, Ishii N, Tsuchida M, Okawa H, Sugamura K, Yata J

Abstract excerpt

We previously examined the Ig heavy (H) chain gene of pretransplant patients with X-linked SCID (XSCID), having defects in the gene of the IL-2 receptor (R) gamma chain. In the present study, we analyzed two post-transplant XSCID patients, in whom T cell-depleted haploidentical BMT resulted in ly...

Topics

Base Sequence
Bone Marrow Transplantation
Cell Differentiation
Cell Division
Child, Preschool
Genetic Linkage
Humans
Immunoglobulin Heavy Chains
Male
Molecular Sequence Data
Mutation
Severe Combined Immunodeficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

X Chromosome

Source

Identifiers

PMID: 8750273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8750273-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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T cell reconstitution by haploidentical BMT does not restore the diversification of the Ig heavy chain gene in patients with X-linked SCID.PMID 8750273Read ↗

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