Article
Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.
Biochemical and biophysical research communications - 27 Feb 1995
Kelly S L, Lamb D C, Corran A J, Baldwin B C, Kelly D E
Abstract excerpt
Azole antifungal compounds inhibit sterol 14 alpha-demethylase. They are used extensively for the treatment of immunocompromised patients where fungal infection is common and often results in death. Resistance to the compounds is emerging, particularly in fungal pathogens obtained from AIDS patie...
Topics
- Antifungal Agents
- Azoles
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Drug Resistance
- Ergosterol
- Genetic Complementation Test
- Mutation
- Oxidoreductases
- Saccharomyces cerevisiae
- Sterol 14-Demethylase
- Sterols
- Suppression, Genetic