Altered P450 activity associated with direct selection for fungal azole resistance.

doi:10.1016/0014-5793(95)01102-k

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Article

Altered P450 activity associated with direct selection for fungal azole resistance.

FEBS letters - 30 Oct 1995

Joseph-Horne T, Hollomon D, Loeffler R S, Kelly S L

Abstract excerpt

Azole antifungals inhibit CYP51A1-mediated sterol 14 alpha-demethylation and the mechanism(s) of resistance to such compounds in Ustilago maydis were examined. The inhibition of growth was correlated with the accumulation of the substrate, 24-methylene-24,25-dihydrolanosterol (eburicol), and depl...

Topics

Azoles
Carbon Radioisotopes
Cytochrome P-450 Enzyme System
Drug Resistance, Microbial
Molecular Structure
Mutation
Oxidoreductases
Sterol 14-Demethylase
Sterols
Substrate Specificity
Triazoles
Ustilago

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