Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.

doi:10.1111/j.1574-6968.1995.tb07445.x

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Article

Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.

FEMS microbiology letters - 15 Mar 1995

Joseph-Horne T, Manning N J, Hollomon D, Kelly S L

Abstract excerpt

Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated c...

Topics

Antifungal Agents
Azoles
Drug Resistance, Microbial
Mutation
Oxidoreductases
Phenotype
Sterols
Ustilago

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