Article
Familial adenomatous polyposis: mutation at codon 1309 and early onset of colon cancer.
Lancet (London, England) - 12 Mar 1994
Caspari R, Friedl W, Mandl M, Möslein G, Kadmon M, Knapp M, Jacobasch K H, Ecker K W, Kreissler-Haag D, Timmermanns G
Abstract excerpt
The clinical course of familial adenomatous polyposis (FAP) varies considerably between patients. Prediction of the severity of the disease is important in the interest of effective cancer prevention. We examined whether age at diagnosis of FAP due to gastrointestinal symptoms and age at death due to colorectal cancer are related to the site of mutation in the responsible gene. 225 families with FAP were screened...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Age of Onset
- Aged
- Child
- Child, Preschool
- Codon
- Colonic Neoplasms
- Exons
- Genes, APC
- Humans