Identification of PiZ gene products in liver tissue by a monoclonal antibody specific for the Z mutant of alpha 1-antitrypsin.

doi:10.1016/0168-8278(91)90842-y

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Article

Identification of PiZ gene products in liver tissue by a monoclonal antibody specific for the Z mutant of alpha 1-antitrypsin.

Journal of hepatology - 1 May 1991

Callea F, Brisigotti M, Faa G, Lucini L, Eriksson S

Abstract excerpt

Globular inclusions of abnormal alpha 1-antitrypsin (AAT) in the rough endoplasmic reticulum of hepatocytes is a characteristic feature of AAT deficiency of the PiZ phenotype. It is also seen in some rare M-like Pi types (including M-Cagliari) having low plasma AAT levels and M-like mobility on i...

Topics

Antibodies, Monoclonal
Female
Humans
Immunohistochemistry
Liver
Male
Mutation
Phenotype
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

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