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Article

The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients.

Archives of dermatology - 1 Feb 1995

Snow J L, Gibson L E

Abstract excerpt

BACKGROUND: Thiopurine methyltransferase (TPMT) is one of three major enzymes involved in the metabolism of azathioprine and its active metabolite 6-mercaptopurine. Thiopurine methyltransferase activity is determined by an allelic polymorphism for either high (TPMTH) or low (TPMTL) enzyme activit...

Topics

Adult
Aged
Azathioprine
Female
Genetic Variation
Genotype
Humans
Male
Methyltransferases
Middle Aged
Skin Diseases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7857117

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7857117-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients.PMID 7857117Read ↗

An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.Semantic proximity Read ↗

Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis.Semantic proximity Read ↗

Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine.Semantic proximity Read ↗

Thiopurine S-methyltransferase genotypic analysis in autoimmune bullous diseases.Semantic proximity Read ↗

TPMT*26 (208F-->L), a novel mutation detected in a Chinese.Semantic proximity Read ↗

Clinical utility of thiopurine S-methyltransferase genotyping.Semantic proximity Read ↗

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.Semantic proximity Read ↗

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.Semantic proximity Read ↗

[Phenotype and genotype of thiopurine methyltransferase in Chilean individuals].Semantic proximity Read ↗

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis.Semantic proximity Read ↗

Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.Semantic proximity Read ↗

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