Article
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Apr 2001
Evans W E, Hon Y Y, Bomgaars L, Coutre S, Holdsworth M, Janco R, Kalwinsky D, Keller F, Khatib Z, Margolin J, Murray J, Quinn J, Ravindranath Y, Ritchey K, Roberts W, Rogers Z R, Schiff D, Steuber C, Tucci F, Kornegay N, Krynetski E Y, Relling M V
Abstract excerpt
PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their clinical management. PATIENTS AND METHODS: TPMT phenotype and thiopurine metabolism were assessed in all patients referred between 1994 and 1999 for evaluation of excessive toxicity while receiving MP or AZA. TPMT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.