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Article

TPMT*26 (208F-->L), a novel mutation detected in a Chinese.

British journal of clinical pharmacology - 1 Jul 2009

Kham Shirley Kow Yin, Soh Chin Kok, Aw Derrick Chen Wee, Yeoh Allen Eng Juh

Abstract excerpt

AIMS: Azathioprine, mercaptopurine and thioguanine are commonly used to treat autoimmune disorders, leukaemia and solid organ transplantation. However, azathiopurine and its metabolites can also cause adverse reactions such as myelosuppression. These manifestations may be attributed to polymorphisms or mutations in the thiopurine methyltransferase (TPMT) gene that might result in low TPMT enzyme activity. Our aim...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19660010
DOI: 10.1111/j.1365-2125.2009.03405.x
PMCID: PMC2732947

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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TPMT*26 (208F-->L), a novel mutation detected in a Chinese.PMID 19660010Read ↗

Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).Semantic proximity Read ↗

Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression.Semantic proximity Read ↗

Nomenclature for alleles of the thiopurine methyltransferase gene.Semantic proximity Read ↗

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Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

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An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions.Semantic proximity Read ↗

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Semantic proximity Read ↗

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Three novel thiopurine S-methyltransferase allelic variants (TPMT*20, *21, *22) - association with decreased enzyme function.Semantic proximity Read ↗

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