Article
Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells.
Cancer research - 15 Feb 1995
Dawson T P, Radulescu A, Wynford-Thomas D
Abstract excerpt
There is substantial evidence supporting the existence of insulin-like growth factor 1 (IGF-1) autocrine circuits in many tumor types, although the underlying inducing event has remained undefined. In order to address this matter, we have generated several immortalized human thyroid epithelial ce...
Topics
- Base Sequence
- Blotting, Northern
- Cell Division
- Cell Line
- Epithelium
- Gene Expression Regulation
- Genes, ras
- Humans
- Immunohistochemistry
- Insulin-Like Growth Factor I
- Molecular Sequence Data
- Mutation
- Oncogene Protein p21(ras)
- RNA, Messenger
- Thyroid Gland
- Transfection
- Zinc