Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells.

Abstract excerpt

There is substantial evidence supporting the existence of insulin-like growth factor 1 (IGF-1) autocrine circuits in many tumor types, although the underlying inducing event has remained undefined. In order to address this matter, we have generated several immortalized human thyroid epithelial cell lines containing a zinc-inducible mutant H-ras gene and used these to investigate the relationship between...

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