Etiology and pathogenesis of human neural tube defects

Abstract excerpt

Research into neural tube defects (NTDs) is now entering a rapid phase as advances in experimental embryology and genetics, together with new insights from clinical epidemiology, provide testable hypotheses of the etiology and pathogenesis of these defects. Especially important have been contributions from the study of mouse mutants. The embryologic mechanisms responsible for upper and lower NTDs appear to be...

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