Polymorphism in the multi-phosphorylation domain of the human neurofilament heavy-subunit-encoding gene.

doi:10.1016/0378-1119(93)90211-k

Back to search

Article

Polymorphism in the multi-phosphorylation domain of the human neurofilament heavy-subunit-encoding gene.

Gene - 15 Oct 1993

Figlewicz D A, Rouleau G A, Krizus A, Julien J P

Abstract excerpt

The C-terminal region of the human neurofilament heavy subunit (NEFH) contains a unique functional domain consisting of 43 repeat motifs of the amino acids (aa) Lys-Ser-Pro (KSP) with either 3- or 5-aa spacers in between. Past studies have demonstrated that the serine in these KSP motifs can be p...

Topics

Alleles
Amino Acid Sequence
Base Sequence
DNA
Genetic Variation
Humans
Molecular Sequence Data
Neurofilament Proteins
Phosphorylation
Polymerase Chain Reaction
Polymorphism, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.