Article

Mutations in the tail domain of the neurofilament heavy chain gene increase the risk of amyotrophic lateral sclerosis

2022-11-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Genetic variation in the neurofilament heavy chain gene ( NEFH ) has been convincingly linked to the pathogenesis of multiple neurodegenerative diseases, however, the relationship between NEFH mutations and ALS susceptibility has not been robustly explored. We therefore wanted to determine if genetic variants in NEFH modify ALS risk. <h4>Methods</h4> We performed fixed and rand...

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Literature Corpus work: 8ce607d7-9837-545b-a443-e5f2ea1ed493
DOI: 10.1101/2022.11.03.22281905

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