Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice.

doi:10.1093/hmg/4.8.1251

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Article

Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice.

Human molecular genetics - 1 Aug 1995

Phelps S F, Hauser M A, Cole N M, Rafael J A, Hinkle R T, Faulkner J A, Chamberlain J S

Abstract excerpt

Duchenne and Becker muscular dystrophy are caused by defects in the dystrophin gene, and are candidates for treatment by gene therapy. We have shown previously that overexpression of a full-length dystrophin cDNA prevents the development of dystrophic symptoms in mdx mice. We show here that this functional correction can be achieved by expressing the full-length muscle isoform at a lower level than is present in...

Topics

Animals
DNA, Complementary
Diaphragm
Dystrophin
Female
Gene Expression
Genetic Therapy
Genetic Vectors
Humans
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mice, Transgenic

Muscle, Skeletal

Muscular Dystrophies

Muscular Dystrophy, Animal

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7581361
DOI: 10.1093/hmg/4.8.1251

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7581361-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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