Article
The dystrophin associated protein complex in zebrafish.
Human molecular genetics - 15 Mar 2003
Guyon J R, Mosley A N, Zhou Y, O'Brien K F, Sheng X, Chiang K, Davidson A J, Volinski J M, Zon L I, Kunkel L M
Abstract excerpt
Many cases of muscular dystrophy in humans are caused by mutations in members of the dystrophin associated protein complex (DAPC). Zebrafish are small vertebrates whose bodies are composed predominantly of skeletal muscle, making them attractive models for studying mammalian muscle disorders. Potential orthologs to most of the human DAPC proteins have been found in zebrafish by database screening. Expression of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Western
- Cell Membrane
- Chromosome Mapping
- Cloning, Molecular
- Cytoplasm
- DNA, Complementary
- Databases as Topic
- Dystrophin
- Electrophoresis, Polyacrylamide Gel
- Exons
- Gene Library