Article
Similarities between somatic cells overexpressing the mos oncogene and oocytes during meiotic interphase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1994
Fukasawa K, Murakami M S, Blair D G, Kuriyama R, Hunt T, Fischinger P, Vande Woude G F
Abstract excerpt
The mos protooncogene encodes a serine/threonine kinase and is a key regulator of oocyte meiotic maturation. After acute infection of Swiss 3T3 cells with virus containing the v-mos oncogene, cells expressing high levels of v-Mos round up and detach from the monolayer (floating cells), while cells that remain attached express 10-fold lower levels of v-Mos and are transformed. The floating cells are growth...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Transformation, Neoplastic
- Cyclins
- Female
- Gene Expression Regulation, Neoplastic
- Genes, mos
- Interphase
- Meiosis