MOS mutation causes female infertility with large polar body oocytes.

doi:10.1080/09513590.2022.2147158

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Article

MOS mutation causes female infertility with large polar body oocytes.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Dec 2022

Jiao Guangzhong, Lian Huayu, Xing Jinhao, Chen Lili, Du Zhaoli, Liu Xiaoyan

Abstract excerpt

The Moloney sarcoma oncogene (MOS) encodes a protein serine/threonine kinase and MOS is expressed at high levels in oocytes undergoing meiotic maturation. The MOS/MAPK pathway is normally required for the maintenance of microtubules and chromatin in a metaphasic state during the meiotic divisions. To determine the pathogenic genes in a female infertile patient due to large polar body oocytes, whole-exome...

Topics

Humans
Female
Polar Bodies
Meiosis
Infertility, Female
Proto-Oncogene Proteins c-mos
Oocytes
Mutation
Sarcoma

Source

Open in PubMed

Identifiers

PMID: 36403623
DOI: 10.1080/09513590.2022.2147158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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