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Bi-allelic mutations in MOS cause female infertility characterized by preimplantation embryonic arrest.

Human reproduction (Oxford, England) - 1 Mar 2022

Zeng Yang, Shi Juanzi, Xu Shiru, Shi Rong, Wu Tonghua, Li Hongyan, Xue Xia, Zhu Yuanchang, Chen Biaobang, Sang Qing, Wang Lei

Abstract excerpt

STUDY QUESTION: Are mutations in MOS (MOS proto-oncogene, serine/threonine kinase) involved in early embryonic arrest in infertile women? SUMMARY ANSWER: We identified mutations in MOS that may cause human female infertility characterized by preimplantation embryonic arrest (PREMBA), and the effects of the mutations in human embryonic kidney 293T (HEK293T cells) and mouse oocytes provided evidence for a causal...

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PMID: 34997960
DOI: 10.1093/humrep/deab281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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