Article
Binding of histone H1e-c variants to CpG-rich DNA correlates with the inhibitory effect on enzymic DNA methylation.
The Biochemical journal - 1 Feb 1995
Santoro R, D'Erme M, Mastrantonio S, Reale A, Marenzi S, Saluz H P, Strom R, Caiafa P
Abstract excerpt
Within the H1 histone family, only some fractions enriched in the H1e-c variants are effective in causing a marked inhibition, in vitro, of enzymic DNA methylation and, in gel retardation and Southwestern blot experiments, in binding double-stranded (ds) CpG-rich oligonucleotides. Both the 6-CpG ds-oligonucleotide and the DNA purified from chromatin fractions enriched in 'CpG islands' are good competitors for the...
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