Article
Specific variants of H1 histone regulate CpG methylation in eukaryotic DNA.
Gene - 19 May 1995
Strom R, Santoro R, D'Erme M, Mastrantonio S, Reale A, Marenzi S, Zardo G, Caiafa P
Abstract excerpt
Upon HPLC fractionation of human placenta or calf thymus H1 histone preparations, only some fractions enriched in the H1e-c variants were able to exert a severe inhibition on in vitro enzymatic DNA methylation. These fractions, though similar to the other variants in interacting with genomic DNA, were also the only ones which could bind CpG-rich ds-oligodeoxyribonucleotides (oligos). Both the 6-CpG ds-oligo and...
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