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Article

Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain.

Chemistry & biology - 25 May 2012

Bashtrykov Pavel, Jankevicius Gytis, Smarandache Anita, Jurkowska Renata Z, Ragozin Sergey, Jeltsch Albert

Abstract excerpt

The maintenance methylation of hemimethylated CpG sites by the DNA methyltransferase Dnmt1 is the molecular basis of the inheritance of DNA methylation patterns. Based on structural data and kinetics obtained with a truncated form of Dnmt1, an autoinhibition model for the specificity of Dnmt1 was proposed in which unmethylated DNA binds to Dnmt1's CXXC domain, which prevents its methylation. We have prepared CXXC...

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Identifiers

PMID: 22633409
DOI: 10.1016/j.chembiol.2012.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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