Article
Specific inhibitory effect of H1e histone somatic variant on in vitro DNA-methylation process.
Biochemical and biophysical research communications - 7 Mar 1996
Zardo G, Santoro R, D'Erme M, Reale A, Guidobaldi L, Caiafa P, Strom R
Abstract excerpt
H1e and H1c histone variants were purified from mouse L929 fibroblasts using a reverse phase HPLC, and their effect on in vitro DNA methylation was investigated, together with their ability to bind unmethylated or methylated CpG-rich 44bp oligonucleotides. In a "physiological" range of H1:DNA ratios only H1e, at variance from H1c, was found to cause a marked inhibition of in vitro enzymic DNA methylation. It was...
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