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A unique insertion in the S gene of surface antigen-negative hepatitis B virus Chinese carriers

1 Feb 1995

Abstract excerpt

The presence of unique hepatitis B virus (HBV) variants has been investigated in two Chinese patients with chronic liver disease, whose sera were positive for HBV-DNA by dot blot hybridization or polymerase chain reaction (PCR) but hepatitis B surface antigen (HBsAg)-negative by conventional polyclonal antibody based immunoassays. PCR amplification of HBV-DNA followed by direct sequencing showed an insertion of...

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PMID: 7843693
DOI: 10.1002/hep.1840210202

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