Article
High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum.
The Journal of general virology - 1 May 2000
Weinberger K M, Bauer T, Böhm S, Jilg W
Abstract excerpt
Chronic carriers of hepatitis B virus (HBV) usually show hepatitis B surface antigen (HBsAg) in their sera, which is considered the best marker for acute and chronic HBV infection. In some individuals, however, this antigen cannot be detected by routine serological assays despite the presence of virus in liver and peripheral blood. One reason for this lack of HBsAg might be mutations in the part of the molecule...
Topics
- Amino Acid Substitution
- DNA, Viral
- Genetic Variation
- Hepatitis B Antibodies
- Hepatitis B Core Antigens
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Mutation