Article
A possible screening test for inherited p53-related defects based on the apoptotic response of peripheral blood lymphocytes to DNA damage.
British journal of cancer - 1 Sept 1995
Camplejohn R S, Perry P, Hodgson S V, Turner G, Williams A, Upton C, MacGeoch C, Mohammed S, Barnes D M
Abstract excerpt
The cellular response, in terms of cell cycle arrest(s) and apoptosis, to radiation-induced DNA damage was studied. Experiments were performed on both mitogen-stimulated and resting peripheral blood lymphocytes (PBLs) from normal and cancer-prone (C-P) individuals. The C-P individuals comprised t...
Topics
- Adult
- Apoptosis
- Cell Cycle
- Child, Preschool
- DNA
- DNA Damage
- Disease Susceptibility
- Flow Cytometry
- G1 Phase
- Genes, p53
- Genetic Testing
- HeLa Cells
- Humans
- Immunohistochemistry
- Li-Fraumeni Syndrome