Article
Pedigree analysis package vs. MIXD: fitting the mixed model on a large pedigree.
Genetic epidemiology - 1 Jan 1996
Olshen A B, Wijsman E M
Abstract excerpt
Results of a simulation study with two methods of analysis of data simulated under the mixed model on a 232-member pedigree are presented. The programs Pedigree Analysis Package (PAP), which approximate the likelihoods needed in a complex segregation analysis, and MIXD, which uses Monte Carlo Mar...
Topics
- Analysis of Variance
- Bias
- Gene Frequency
- Genotype
- Humans
- Likelihood Functions
- Markov Chains
- Models, Genetic
- Monte Carlo Method
- Pedigree
- Reproducibility of Results
- Software Validation