Article
Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma.
Cancer research - 1 Feb 1995
Villa E, Camellini L, Dugani A, Zucchi F, Grottola A, Merighi A, Buttafoco P, Losi L, Manenti F
Abstract excerpt
The development of hepatocellular carcinoma (HCC) in addition to cirrhosis affects males in a significantly higher proportion than females. Liver estrogen receptors increase when HCC develops in males; however, these tumors usually respond poorly to antiestrogens. We have, therefore, hypothesized that, similar to breast cancer, estrogen receptors in males with HCC may be mutated. Variant estrogen receptor...
Topics
- Blotting, Northern
- Carcinoma, Hepatocellular
- Female
- Gene Expression
- Genetic Variation
- Humans
- Liver
- Liver Neoplasms
- Male
- Middle Aged
- Polymerase Chain Reaction