Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Wild-Type and Variant Estrogen Receptor Alpha in Liver Carcinogenesis and Tumor Progression

24 Feb 2011

Abstract excerpt

Although estrogen receptors (ERs) are expressed in human hepatocellular carcinoma (HCC), several clinical trials have failed to demonstrate the efficacy of antiestrogen treatment in HCC patients. Recently, the identification of several ER splicing variants has enlightened the complex nature of estrogen signaling in peripheral tissues; this may help understanding estrogen role in either nontumoral or malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21348637
DOI: 10.1089/omi.2010.0108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Wild-Type and Variant Estrogen Receptor Alpha in Liver Carcinogenesis and Tumor ProgressionPMID 21348637Read ↗

Quantitative profiles of the mRNAs of ER-alpha and its novel variant ER-alpha36 in breast cancers and matched normal tissues.Semantic proximity Read ↗

Variant estrogen receptors and their role in liver disease.Semantic proximity Read ↗

Identification, cloning, and expression of human estrogen receptor-α36, a novel variant of human estrogen receptor-α66Semantic proximity Read ↗

Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma.Semantic proximity Read ↗

Characterization of the fundamental properties of the N-terminal truncation (Δ exon 1) variant of estrogen receptor α in the rat.Semantic proximity Read ↗

A variant of estrogen receptor-α, hER-α36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signalingSemantic proximity Read ↗

Estrogen Receptor Variant ER-α36 Facilitates Estrogen Signaling Via EGFR Signaling in GlioblastomaSemantic proximity Read ↗

Hepatocellular carcinoma and estrogen receptors: Polymorphisms and isoforms relations and implications.Semantic proximity Read ↗

Estrogen receptor alpha mRNA variant lacking exon 5 is co-expressed with the wild-type in endometrial adenocarcinoma.Semantic proximity Read ↗

The pathophysiological role of estrogen receptor variants in human breast cancer.Semantic proximity Read ↗

Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma.Semantic proximity Read ↗

Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.