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Article

Variant estrogen receptors and their role in liver disease.

Molecular and cellular endocrinology - 31 Jul 2002

Villa Erica, Colantoni Alessandra, Grottola Antonella, Ferretti Ilva, Buttafoco Paola, Bertani Helga, De Maria Nicola, Manenti Federico

Abstract excerpt

The liver presents estrogen receptors alpha and beta. As for breast cancer, a variant form of estrogen receptor alpha transcript (ER) has been described in hepatocellular carcinoma (HCC). It is derived by an exon 5-deleted transcript (vER), which lacks the hormone-binding domain of the receptor but, being intact in the DNA-binding domain, maintains constitutive transcriptional activity. HCCs presenting vER have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12161003
DOI: 10.1016/s0303-7207(02)00097-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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