Article
Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects.
Seminars in vascular medicine - 1 Aug 2004
Smelt A H M, de Beer F
Abstract excerpt
In humans, apolipoprotein E (apoE) is a polymorphic protein of which three common isoforms can be distinguished, designated apoE2, apoE3, and apoE4. This genetic variation is associated with different plasma lipoprotein levels, different response to diet and lipid-lowering therapy, and a variable risk for cardiovascular disease and Alzheimer's disease. An example of an apoE-mediated, autosomal recessive, lipid...
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