Article
Dimerization of beta B2-crystallin: the role of the linker peptide and the N- and C-terminal extensions.
Protein science : a publication of the Protein Society - 1 Sept 1994
Trinkl S, Glockshuber R, Jaenicke R
Abstract excerpt
beta B2- and gamma B-crystallins of vertebrate eye lens are 2-domain proteins in which each domain consists of 2 Greek key motifs connected by a linker peptide. Although the folding topologies of beta B2- and gamma B-domains are very similar, gamma B-crystallin is always monomeric, whereas beta B...
Topics
- Amino Acid Sequence
- Base Sequence
- Circular Dichroism
- Cloning, Molecular
- Crystallins
- Escherichia coli
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Recombinant Proteins
- Spectrometry, Fluorescence
- Spectrophotometry, Ultraviolet
- Structure-Activity Relationship
- Urea