Article
Structure of the crystallins.
Eye (London, England) - 1 Jun 1999
Slingsby C, Clout N J
Abstract excerpt
The lens is formed from two protein superfamilies, the alpha- and beta gamma-crystallins. Representative three-dimensional structures show they both have a basic 2-beta-sheet domain fold, with the beta gamma-domain being made from two intercalating Greek keys. X-ray structures of monomeric gamma-crystallins and simple oligomeric beta-crystallins show how multiple gene duplications can give rise to highly...
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