Unusual domain pairing in a mutant of bovine lens gammaB-crystallin.

Abstract excerpt

beta gamma-Crystallins from the eye lens are proteins consisting of two domains joined by a short linker. All 3D structures solved so far reveal a similar pseudo-2-fold pairing of the domains, reflecting their presumed ancient origin from a single-domain homodimer. Here we report the 2.2 A X-ray structure of the N-terminal domain of gammaB-crystallin, bearing a mutation of a residue involved in domain contacts in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cattle
• Share to Crystallins
• Share to Crystallography, X-Ray