Unusual domain pairing in a mutant of bovine lens gammaB-crystallin.

Abstract excerpt

beta gamma-Crystallins from the eye lens are proteins consisting of two domains joined by a short linker. All 3D structures solved so far reveal a similar pseudo-2-fold pairing of the domains, reflecting their presumed ancient origin from a single-domain homodimer. Here we report the 2.2 A X-ray...

Topics

• Animals
• Cattle
• Crystallins
• Crystallography, X-Ray
• Models, Molecular
• Mutation
• Protein Conformation
• gamma-Crystallins