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Article

Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D).

Virology - 20 Jul 2005

Marozsan Andre J, Kuhmann Shawn E, Morgan Thomas, Herrera Carolina, Rivera-Troche Enid, Xu Serena, Baroudy Bahige M, Strizki Julie, Moore John P

Abstract excerpt

We describe the generation of two genetically related human immunodeficiency virus type 1 (HIV-1) isolates highly (>20,000-fold) resistant to the small molecule CCR5 inhibitor, SCH-417690 (formerly SCH-D). Both viruses were cross-resistant to other small molecules targeting entry via CCR5, but they were inhibited by some MAbs against the same coreceptor on primary CD4+ T-cells. The resistant isolates remained...

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Source

Identifiers

PMID: 15935415
DOI: 10.1016/j.virol.2005.04.035

Genes

CCR5
CD4
CXCR4
C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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