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Article

Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes.

Somatic cell and molecular genetics - 1 Sept 1994

Ogburn C E, Turker M S, Kavanagh T J, Disteche C M, Smith A C, Fukuchi K, Martin G M

Abstract excerpt

Stable, oxygen-resistant cell lines (O2R) were isolated from P19 and P19H22 (APRT hemizygote) mouse embryonic carcinoma cells by serial exposures of increasing durations to 95% O2. Neurally differentiated progeny were also oxygen-resistant. P19O2R exhibited reduced oxygen-mediated micronucleation and a 10- to 20-fold reduction of the forward mutation rate at the HPRT locus in 20% O2. P19H22O2R cells showed...

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PMID: 7825058
DOI: 10.1007/BF02257453

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APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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