Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes.

doi:10.1007/BF02257453

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Article

Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes.

Somatic cell and molecular genetics - 1 Sept 1994

Ogburn C E, Turker M S, Kavanagh T J, Disteche C M, Smith A C, Fukuchi K, Martin G M

Abstract excerpt

Stable, oxygen-resistant cell lines (O2R) were isolated from P19 and P19H22 (APRT hemizygote) mouse embryonic carcinoma cells by serial exposures of increasing durations to 95% O2. Neurally differentiated progeny were also oxygen-resistant. P19O2R exhibited reduced oxygen-mediated micronucleation...

Topics

Adenine Phosphoribosyltransferase
Animals
Cell Separation
Embryo, Mammalian
Feasibility Studies
Gamma Rays
Hypoxanthine Phosphoribosyltransferase
Karyotyping
Male
Mice
Mice, Inbred C3H
Mutation
Oxygen
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7825058
DOI: 10.1007/BF02257453

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7825058-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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