A free-radical hypothesis for the instability and evolution of genotype and phenotype in vitro.

doi:10.1007/BF00570888

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Article

A free-radical hypothesis for the instability and evolution of genotype and phenotype in vitro.

Cytotechnology - 1 Jan 1992

Parchment R E, Natarajan K

Abstract excerpt

It has been known for several decades that cultured murine cells undergo a defined series of changes, i.e., an in vitro evolution, which includes crisis, spontaneous transformation ('immortalization'), aneuploidy, and spontaneous neoplastic transformation. These changes have been shown to be caus...

Topics

Aneuploidy
Animals
Blood
Cell Death
Cell Transformation, Neoplastic
Cells, Cultured
Cellular Senescence
Culture Media
Culture Media, Serum-Free
Free Radicals
Genotype
Mice
Models, Biological
Oncogenes
Organ Specificity
Oxidation-Reduction
Oxidoreductases
Oxygen

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