Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia

Abstract excerpt

In vivo, mammalian cells reside in an environment of 0.5–10% O2 (depending on the tissue location within the body), whilst standard in vitro cell culture is carried out under room air. Little is known about the effects of this hyperoxic environment on treatment-induced oxidative stress, relative to a physiological oxygen environment. In the present study we investigated the effects of long-term culture under...

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