Article
Papilloedema and MRI enhancement of the prechiasmal optic nerve at the acute stage of Leber hereditary optic neuropathy.
Journal of neurology, neurosurgery, and psychiatry - 1 May 2010
Lamirel Cédric, Cassereau Julien, Cochereau Isabelle, Vignal-Clermont Catherine, Pajot Olivier, Tanguy Jean-Yves, Zanlonghi Xavier, Reynier Pascal, Amati-Bonneau Patrizia, Dubas Frédéric, Bonneau Dominique, Verny Christophe
Abstract excerpt
The authors report a case of one patient from a family carrying the homoplasmic Leber hereditary optic neuropathy (LHON) G11778A mitochondrial DNA mutation with papilloedema 9 months prior to the acute stage of LHON and still present at the onset of visual loss. During the vision loss, the MRI demonstrated a T2 hyperintensity and an enhancement of the prechiasmal left optic nerve, suggesting the existence of an...
Topics
- Acute Disease
- Blindness
- Cerebral Angiography
- DNA, Mitochondrial
- Female
- Humans
- Intracranial Hypertension
- Magnetic Resonance Imaging
- Mutation
- Optic Atrophy, Hereditary, Leber
- Optic Nerve
- Papilledema