Interleukin-6 responsiveness and cell-specific expression of the rat kininogen gene.

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Article

Interleukin-6 responsiveness and cell-specific expression of the rat kininogen gene.

The Journal of biological chemistry - 15 Feb 1991

Chen H M, Considine K B, Liao W S

Abstract excerpt

The serum concentration of rat T1 kininogen increases 20-30-fold in response to acute inflammation, an induced hepatic synthesis regulated primarily at the transcriptional level. To analyze the cis-regulatory elements responsible for the induced transcription, we fused a 1.6-kilobase segment of t...

Topics

Animals
Chimera
Chloramphenicol O-Acetyltransferase
Dexamethasone
Gene Expression Regulation
Glucocorticoids
Humans
Interleukin-6
Kininogens
Liver
Mutation
Promoter Regions, Genetic
Rats
Thymidine Kinase
Transcription, Genetic
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1993668

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1993668-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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