Regulation of collagen type I and biglycan mRNA levels by hormones and growth factors in normal and immortalized osteoblastic cell lines.

doi:10.1002/jbmr.5650090905

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Article

Regulation of collagen type I and biglycan mRNA levels by hormones and growth factors in normal and immortalized osteoblastic cell lines.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1994

Thiébaud D, Guenther H L, Porret A, Burckhardt P, Fleisch H, Hofstetter W

Abstract excerpt

Growth factors, such as transforming growth factor beta (TGF-beta) and insulin-like growth factors (IGF) I and II, have been shown to exert anabolic effects on bone cells in vitro. Hormones, such as PTH and probably insulin and growth hormone, were recently shown to stimulate bone formation in vivo as well. The aim of the present study was to assess by northern blots, which were quantitated by densitometry, the...

Topics

Animals
Biglycan
Blotting, Northern
Cell Line
Collagen
Dose-Response Relationship, Drug
Extracellular Matrix Proteins
Gene Expression Regulation, Developmental
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor II

Osteoblasts

Osteocalcin

Osteonectin

Osteopontin

Parathyroid Hormone

Peptide Fragments

Phenotype

Proteoglycans

Source

Open in PubMed

Identifiers

PMID: 7817818
DOI: 10.1002/jbmr.5650090905

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7817818-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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