Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells.

doi:10.1007/BF02555007

Back to search

Article

Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells.

Calcified tissue international - 1 Apr 1990

Fraser J D, Price P A

Abstract excerpt

The synthesis of matrix Gla protein (MGP) and bone Gla protein (BGP) have been shown to be mutually exclusive in all osteosarcoma cell lines investigated. In the cell lines that produce the respective proteins, synthesis is stimulated by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) within the first sev...

Topics

Animals
Biomarkers, Tumor
Calcitriol
Calcium-Binding Proteins
Extracellular Matrix Proteins
Neoplasm Proteins
Osteocalcin
Osteosarcoma
Phenotype
RNA, Messenger
Tumor Cells, Cultured
Matrix Gla Protein

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.