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Article

Comparative genomic analysis of tumors: detection of DNA losses and amplification.

3 Jan 1995

Abstract excerpt

We demonstrate the use of representational difference analysis for cloning probes that detect DNA loss and amplification in tumors. Using DNA isolated from human tumor cell lines to drive hybridization against matched normal DNA, we were able to identify six genomic regions that are homozygously deleted in cultured cancer cells. When this method was applied in the reverse way, using normal DNA to drive...

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Identifiers

PMID: 7816807
DOI: 10.1073/pnas.92.1.151

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Source receipt: pubmed, retrieved 7 Sept 2026.

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