Article
Modeling non-random deletions in cancer.
Seminars in cancer biology - 1 Feb 2007
Kost-Alimova Maria, Imreh Stefan
Abstract excerpt
Chromosome deletions do abound in cancer and are detected in certain regions in a non-random manner. Although their relevance remains elusive, it is a general agreement that segmental losses provide the cell with selective growth advantage. Consequently these may contain genes and/or regulatory sequences that control normal growth and inhibit malignancy. We have developed a monochromosomal hybrid based...
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